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NCCN Guidelines for Endometrial Carcinoma and Uterine Neoplasms Study Guide

This guide provides an overview of endometrial cancer treatment, covering surgical staging, adjuvant therapies, and systemic treatments like immunotherapy and targeted therapies. It also discusses management of recurrent disease and the importance of molecular profiling in treatment decisions.

Save this study guide to your study set

Your learning path

Management of Endometrial Carcinoma and Uterine Sarcoma

NCCN Guidelines for Uterine Neoplasms

Clinical practice guidelines for the management of endometrial carcinoma and uterine sarcoma including molecular analysis, surgical staging, and systemic therapy.

Endometrial carcinoma
Surgical staging
Molecular analysis
Fertility-sparing options
Ovarian preservation
Systemic therapy
Biomarker-directed therapy
Immunotherapy-related toxicities
Serous carcinoma
Clear cell carcinoma
Carcinosarcoma
Low-grade endometrial stromal sarcoma
Adenosarcoma
Hormonal therapy
Radiation therapy
MSI-H/dMMR testing
TMB-H testing
HER2 testing
POLE mutations

NCCN Guidelines for Endometrial Carcinoma

Clinical guidelines for the evaluation, staging, and primary treatment of uterine neoplasms including endometrial carcinoma and uterine sarcoma.

endometrial carcinoma
preoperative evaluation
surgical staging
endometrioid histology
FIGO staging
adjuvant treatment
external beam radiation therapy
vaginal brachytherapy
systemic therapy
total hysterectomy and bilateral salpingo-oophorectomy
lymphovascular space invasion
mismatch repair deficiency

Management of Endometrial Carcinoma

NCCN Guidelines for the management of endometrial carcinoma including surgical staging, adjuvant treatment, and fertility-sparing options.

Endometrial carcinoma
Surgical staging
Adjuvant treatment
Endometrioid histology
Fertility-sparing options
Ovarian preservation
Systemic therapy
Radiation therapy
FIGO staging
Lymphovascular space invasion (LVSI)

Endometrial Carcinoma Treatment and Management

NCCN Guidelines for the management of endometrial carcinoma including therapy for locoregional relapse, disseminated metastases, and surgical staging.

Locoregional relapse therapy
Disseminated metastases treatment
Surgical staging
Systemic therapy
Radiation therapy for uterine cancer
Serous carcinoma management
Clear cell carcinoma management
External beam radiation therapy (EBRT)
Vaginal brachytherapy
FIGO staging

Endometrial Carcinoma Pathology and Surgical Staging

Principles of pathologic assessment, molecular analysis, imaging, and surgical staging for endometrial carcinoma including sentinel lymph node mapping.

Pathologic assessment
Molecular subgroups
POLE-mutated
Microsatellite instability-high (MSI-H)
Mismatch repair deficient (dMMR)
No specific molecular profile (NSMP)
Immunohistochemical (IHC) staining
Sentinel lymph node (SLN) mapping
Ultrastaging
Lymph node metastasis
Total hysterectomy + bilateral salpingo-oophorectomy (TH/BSO)
Radical hysterectomy (RH)
Lymphovascular space invasion (LVSI)
Myometrial invasion
Pelvic MRI
Computed tomography (CT)
Fluorodeoxyglucose (FDG)-PET/CT

Endometrial Carcinoma and Uterine Sarcoma Management

Clinical guidelines for the surgical staging, systemic therapy, and hormonal treatment of endometrial carcinoma and uterine sarcoma.

Sentinel lymph node mapping algorithm
Surgical staging of endometrial cancer
Systemic therapy for advanced endometrial carcinoma
First-line therapy for recurrent disease
Biomarker-directed therapy
Hormonal therapy for recurrent or metastatic disease
Uterine sarcoma primary treatment
Management of high-grade endometrial carcinoma
Chemoradiation therapy
Immunotherapy regimens

Uterine Sarcoma Pathology and Molecular Analysis

Principles of pathologic assessment and molecular profiling for various uterine sarcoma subtypes including leiomyosarcoma, endometrial stromal sarcoma, and inflammatory myofibroblastic tumor.

Pathologic assessment
Molecular profiling in gynecologic mesenchymal malignancies
Leiomyosarcoma (LMS) histologic diagnosis
Epithelioid leiomyosarcoma
Myxoid leiomyosarcoma
Low-grade endometrial stromal sarcoma (ESS)
High-grade endometrial stromal sarcoma (ESS)
Perivascular epithelioid cell tumor (PEComa)
Inflammatory myofibroblastic tumor (IMT)
SMARCA4-deficient uterine sarcomas (SDUS)
NTRK-rearranged sarcoma
Genomic risk stratification
Immunohistochemical markers

Pathology, Imaging, and Systemic Therapy for Uterine Sarcoma

Pathology, Imaging, and Therapy for Endometrial Cancer

Principles of pathology, molecular analysis, imaging, and therapy for uterine sarcoma including histologic diagnosis and molecular findings.

Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT)
Rhabdomyosarcoma (RMS) subtypes
Molecular findings and gene fusions
Prognostic factors
Imaging workup and surveillance
First-line therapy for advanced or recurrent disease
Biomarker-directed therapy

Systemic Endocrine Therapy for Uterine Cancer

Hormonal therapies may be considered for patients with ER/PR-positive uterine cancer.

Systemic endocrine therapy
ER/PR-positive uterine cancer
Aromatase inhibitors
Anastrozole
Letrozole
Exemestane
Gonadotropin-releasing hormone (GnRH) analogs
Fulvestrant
Megestrol acetate
Medroxyprogesterone acetate
Ovarian ablation or suppression

Staging and Management of Uterine Neoplasms

Radiation Therapy and Staging for Endometrial Cancer

Principles of radiation therapy for uterine neoplasms, gynecologic survivorship, and AJCC and FIGO staging systems for uterine carcinomas and sarcomas.

External beam radiotherapy
Brachytherapy
Interstitial brachytherapy
Intensity-modulated RT
Target volumes
AJCC Tumor-Node-Metastases staging
FIGO surgical staging
Uterine carcinomas
Leiomyosarcoma
Endometrial stromal sarcoma

Uterine Sarcoma Staging and Classification

This document details AJCC Tumor-Node-Metastases (TNM) and International Federation of Gynecology and Obstetrics (FIGO) surgical staging systems for uterine sarcomas.

AJCC Tumor-Node-Metastases (TNM) staging
FIGO surgical staging systems
Primary tumor assessment
Regional lymph node metastasis
Distant metastasis
Prognostic stage groups
Histologic grade

Surgical Staging in Endometrial Cancer

This document discusses SLN mapping, SLN ultrastaging, and minimally invasive procedures for the surgical staging of endometrial cancer.

SLN mapping
SLN ultrastaging
lymphadenectomy
micrometastasis
isolated tumor cells (ITCs)
minimally invasive procedures
laparoscopy
robotic surgery
laparotomy
lymph node metastasis
adjuvant therapy

Primary Treatment for Endometrial Cancer

NCCN Guidelines for uterine neoplasms delineate treatment categories for pure endometrioid cancer including surgical staging, fertility-sparing progestin-based therapy, and adjuvant options.

endometrioid cancer categories
surgical staging
total hysterectomy
bilateral salpingo-oophorectomy
sentinel lymph node mapping
fertility-sparing therapy
progestin-based therapy
ovarian preservation
adjuvant therapy
lymphadenectomy

Endometrial Cancer Treatment and Management

Management strategies for endometrial cancer including surgical staging, adjuvant radiation therapy, and systemic therapy regimens for uterine-confined and advanced-stage disease.

surgical staging
adjuvant radiation therapy
vaginal brachytherapy
external beam radiation therapy (EBRT)
systemic therapy
carboplatin/paclitaxel
immunotherapy
pembrolizumab
dostarlimab
durvalumab
trastuzumab
endometrioid histologies
uterine serous carcinoma
carcinosarcoma
dMMR status
pMMR status
HER2-positive uterine serous carcinoma

Endometrial Cancer and Uterine Neoplasms Treatment

This document provides a comprehensive list of clinical references regarding systemic therapy, hormonal treatment, and molecular genetic changes in endometrial cancer and uterine sarcomas.

advanced or recurrent endometrial carcinoma
hormonal therapy
systemic therapy
carboplatin and paclitaxel
mismatch repair deficiency
microsatellite instability-high
tumor mutational burden
uterine carcinosarcoma
endometrial stromal sarcoma
JAZF1 and JJAZ1 gene fusion
NTRK gene fusion-positive solid tumors
RET fusion-positive solid tumors

Management of Endometrial Cancer and Uterine Neoplasms

Systemic Therapy and Management of Endometrial Cancer

This document outlines systemic therapy options, biomarker-directed therapies, radiotherapy principles, and post-treatment surveillance for endometrial cancer and uterine neoplasms.

combination chemotherapy regimens
single-agent therapy options
biomarker-directed therapies
MSI-H/dMMR endometrial cancer
TMB-H testing
checkpoint inhibitor combination
NTRK gene fusion-positive endometrial tumors
RET-mutant advanced solid tumors
HER2-positive uterine serous carcinoma
carcinosarcoma treatment
tumor-directed radiotherapy
vaginal brachytherapy
post-treatment surveillance protocol
fertility-sparing treatment

Uterine Neoplasms and Sarcoma Management

Clinical guidelines for the diagnosis, molecular analysis, staging, and treatment of uterine neoplasms including endometrial cancer and various uterine sarcomas.

Endometrial adenocarcinoma
Hormone therapy for hypoestrogenism
Estrogen-receptor modulators (SERMs)
Endometrioid stromal sarcoma (ESS)
Low-grade and high-grade ESS
SMARCA4-deficient uterine sarcomas (SDUSs)
Uterine Leiomyosarcoma (uLMS)
PEComa
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT)
Rhabdomyosarcoma (RMS)
Molecular analysis and genetic signatures
Immunohistochemistry (IHC) markers
FIGO/AJCC staging systems
Bilateral Salpingo-Oophorectomy (BSO)
External Beam Radiation Therapy (EBRT)

Treatment and Surveillance of Uterine Sarcomas

Clinical recommendations for the management, systemic therapy, and post-treatment surveillance of uterine neoplasms including endometrial stromal sarcoma and leiomyosarcoma.

Adjuvant radiotherapy
Systemic endocrine therapy for low-grade ESS
High-grade uterine sarcoma treatment algorithms
Postoperative pelvic radiotherapy for uterine leiomyosarcoma
Adjuvant systemic therapy for stage II and III
Treatment of recurrent or metastatic uterine sarcoma
First-line systemic therapy for high-grade uterine sarcoma
Biomarker-directed therapies for ALK, NTRK, and RET fusions
Post-treatment surveillance protocols
Management of drug reactions and long-term treatment complications

Management and Treatment of Endometrial Cancer

Endometrial Cancer Clinical Management and Research

Clinicians assess the late and long-term effects of gynecologic cancers through patient history, physical examination, imaging, and laboratory testing.

endometrial cancer
gynecologic cancers
myometrial invasion
lymphovascular space invasion
lymph node metastasis
POLE mutations
uterine carcinosarcomas
HER2 testing
mismatch repair immunohistochemistry
DNA MLH1 methylation testing
sentinel lymph node mapping
surgical staging
FIGO staging

Advanced and Recurrent Endometrial Cancer Treatments

Clinical studies and guidelines regarding the treatment of advanced or recurrent endometrial cancer, uterine serous carcinomas, and mismatch repair deficient primary advanced endometrial cancer.

Advanced endometrial cancer
Recurrent endometrial cancer
Uterine serous carcinomas
Mismatch repair deficient endometrial cancer
Durvalumab
Carboplatin
Paclitaxel
Trastuzumab
Bevacizumab
Sandwich therapy
Concurrent chemoradiation

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