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Cervical Cancer Clinical Management Guidelines Study Guide

This guide provides an overview of cervical cancer management, focusing on staging protocols, surgical interventions, and treatment strategies. It details the Revised FIGO staging system, pathological assessment, lymph node staging including sentinel lymph node biopsy, and surgical options such as conization, radical trachelectomy, and radical hysterectomy. The guide also discusses minimally invasive surgery and advanced disease management, referencing NCCN Guidelines.

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Clinical Management, Pathology, and Surgical Staging of Cervical Cancer

NCCN Guidelines for Cervical Cancer Management

Clinical guidelines for the diagnosis, staging, and treatment of squamous cell carcinoma, adenocarcinoma, and small cell neuroendocrine carcinoma of the cervix.

Clinical staging
Fertility sparing primary treatment
Non-fertility sparing primary treatment
Sentinel lymph node mapping
Pelvic lymphadenectomy
Radiation therapy principles
Systemic therapy
Pathologic assessment
Induction chemotherapy
Brachytherapy
Conservative surgery criteria

Cervical Cancer Clinical Management Guidelines

NCCN guidelines detailing clinical staging, primary treatment, surgical staging, and principles of pathology for cervical squamous cell carcinoma and adenocarcinoma.

Clinical staging
Primary treatment
Fertility-sparing surgery
Surgical staging
SLN mapping
Pelvic lymphadenectomy
Brachytherapy
External beam radiation therapy (EBRT)
Concurrent platinum-containing chemotherapy
Principles of pathology
Squamous cell carcinoma
Endocervical adenocarcinoma
HPV-associated and HPV-independent tumors
Silva pattern of invasion
Histologic subtypes
Adjuvant treatment
Locoregional recurrence
Small cell neuroendocrine carcinoma

Principles of Cervical Cancer Pathology and Imaging

This document discusses the histology, immunohistochemistry, and imaging principles for diagnosing and staging cervical cancer, including adenosquamous carcinoma and neuroendocrine carcinoma.

Adenosquamous Carcinoma
Neuroendocrine Carcinoma of the Cervix (NECC)
Small cell neuroendocrine carcinoma
Large cell neuroendocrine carcinoma
Immunohistochemistry (IHC)
p16 overexpression
Pelvis MRI
FDG-PET/CT
FIGO staging
Fertility sparing surgery
Cone biopsy
Radical vaginal trachelectomy
Lymphovascular space invasion (LVSI)

Surgical Staging and Resection of Cervical Cancer

Principles of evaluation and surgical staging for cervical cancer including types of resection, hysterectomy classifications, and sentinel lymph node mapping.

Radical hysterectomy
Simple Type A hysterectomy
Querleu and Morrow classification system
Sentinel lymph node (SLN) mapping
Pelvic exenteration
FIGO staging
Lymphadenectomy
Ultrastaging
Nerve preservation
Conservative surgery criteria

Principles of Cervical Cancer Surgical Staging

Comparison of fertility-sparing procedure types including conization, simple trachelectomy, and radical trachelectomy for cervical cancer resection.

Resection of Cervical Cancer
Conization
Simple Trachelectomy
Radical Trachelectomy
Fertility-sparing procedure types
Surgical staging
Uterine and ovarian sparing
Parametrial resection
Ureteral dissection

Cervical Cancer Treatment and Survivorship Principles

Principles of Radiation Therapy for Cervical Cancer

Guidelines for evaluating and treating cervical cancer using external beam radiation therapy, brachytherapy, and surgical resection considerations.

External beam radiation therapy (EBRT)
Intensity-modulated radiation therapy (IMRT)
Brachytherapy
Intracavitary brachytherapy
Interstitial brachytherapy
Stereotactic body radiation therapy (SBRT)
Image-guided radiation therapy (IGRT)
Target volumes (GTV, CTV, PTV)
Organs at risk (OARs)
Dose-volume histogram (DVH)
Simultaneous integrated boost (SIB)
Normal tissue cumulative dose constraints
Pelvic exenteration types
Radical trachelectomy
Sentinel lymph node mapping

Cervical Cancer Treatment and Survivorship

Clinical guidelines for cervical cancer management including systemic therapy, chemoradiation, and principles of gynecologic survivorship.

GOG/Sedlis criteria
Lymphovascular space invasion (LVSI)
Stromal invasion
Systemic therapy for cervical cancer
First-line therapy
Second-line therapy
Chemoradiation
Small cell neuroendocrine carcinoma
TMB-H tumors
MSI-H/dMMR
HER2(ERBB2)-positive tumors
NTRK gene fusion-positive tumors
Radiation therapy complications
Vaginal stenosis prevention

Cervical Cancer Clinical Management and Treatment

Cervical Cancer Management During Pregnancy

Clinical guidelines for the workup, staging, and primary treatment of cervical cancer in patients during different trimesters of pregnancy.

Cervical cancer workup
Clinical staging during pregnancy
First trimester management
Second trimester management
Third trimester management
Systemic therapy administration
Principles of imaging
Post-delivery treatment
FIGO staging of cervical cancer
LEEP and conization
Pelvic lymphadenectomy
Hysterectomy with fetus in utero

Cervical Cancer Surgical and Biomarker Management

Clinical approaches for cervical cancer including radical hysterectomy, sentinel lymph node mapping, and the use of diagnostic and predictive biomarkers.

Radical hysterectomy (Type C)
Sentinel Lymph Node (SLN) mapping
Pelvic lymphadenectomy
Para-aortic lymph node assessment
Minimally invasive surgical approaches
Silva classification system
Sedlis Criteria
PD-L1 testing
Mismatch Repair / Microsatellite Instability (dMMR/MSI-H)
Tumor mutational burden (TMB)
NTRK gene fusions
HER2 expression
RET gene fusions
p16 IHC status
HPV-independent adenocarcinoma

Cervical Cancer Treatment and Management

Treatment recommendations for cervical cancer include surgery, radiation therapy, and concurrent chemoradiation based on FIGO staging and pathologic risk factors.

FIGO staging system
early-stage cervical cancer treatment
fertility-sparing surgery
radical trachelectomy
cone biopsy
lymphovascular space invasion (LVSI)
sentinel lymph node (SLN) mapping
pelvic lymphadenectomy
concurrent chemoradiation
platinum-containing chemotherapy
adjuvant radiation therapy
Sedlis Criteria
high-risk disease management
post-treatment surveillance
metastatic disease treatment

Systemic Therapy for Cervical Cancer

Preferred and recommended systemic therapy regimens for locally advanced, recurrent, or metastatic cervical cancer including immunotherapy, chemotherapy, and bevacizumab.

Induction chemotherapy with chemoradiotherapy
Pembrolizumab plus chemotherapy with or without bevacizumab
PD-L1–positive recurrent or metastatic cervical cancer
Platinum-based chemotherapy regimens
Cisplatin/paclitaxel and carboplatin/paclitaxel
Atezolizumab plus chemotherapy with bevacizumab
Tisotumab vedotin-tftv
Cemiplimab
Second-line systemic therapy options
Biomarker-based therapies

Cervical Cancer Targeted Therapies and Radiation

NCCN Guidelines discuss biomarker-directed second-line therapies and radiation therapy techniques for cervical cancer management.

cemiplimab
nivolumab
ipilimumab
selpercatinib
larotrectinib
entrectinib
repotrectinib
PD-L1 expression
HER2-positive tumors
RET-gene fusion
NTRK-gene fusion
intensity modulated radiation therapy (IMRT)
brachytherapy
image-guided adaptive brachytherapy (IGABT)
stereotactic body radiotherapy (SBRT)
neuroendocrine carcinoma (NECC)
small cell neuroendocrine carcinoma
p16 positivity
chromogranin
CD56

Cervical Cancer Overview and Survivorship

Cervical cancer treatment can yield cures in early-stage disease, while survivorship care plans and HPV immunization aim to manage history, treatments, and prevention.

Cervical cancer
Survivorship care plans
HPV immunization
Early-stage disease
Concurrent chemoradiation
Refractory systemic cancer
Palliative care
Human papillomavirus (HPV) vaccine
Screening

Cervical Cancer Surgical and Staging References

This document provides a comprehensive list of medical references regarding cervical cancer staging, surgical techniques, and oncological outcomes.

FIGO staging
cervical squamous and adenocarcinoma
fertility-sparing surgery
radical trachelectomy
loop electrosurgical excision procedure
cold knife conization
radical hysterectomy
sentinel lymph node biopsy
para-aortic lymphadenectomy
laparoscopic and robotic-assisted surgery
microinvasive carcinoma

Cervical Cancer Clinical Management and Research

This document provides a comprehensive list of clinical references regarding cervical cancer management, including surgical interventions, molecular biomarkers, and therapeutic outcomes.

radical hysterectomy
robotic-assisted hysterectomy
endocervical adenocarcinoma
FIGO staging classifications
lymphovascular invasion
pembrolizumab
nivolumab
tisotumab vedotin
NTRK fusion-positive solid tumours
HER2 expression
RET fusion-positive solid tumours
chemoradiotherapy
fertility-conserving surgery
radical trachelectomy
sentinel lymph node

Cervical Cancer Treatment and Research References

This document provides a comprehensive list of clinical studies and literature regarding chemotherapy, immunotherapy, and radiation therapy for cervical cancer.

advanced and recurrent cervical carcinoma
cisplatin/paclitaxel and carboplatin/paclitaxel chemotherapy
pembrolizumab
tisotumab vedotin
bevacizumab
docetaxel
gemcitabine
irinotecan
pemetrexed
topotecan
cemiplimab
nivolumab
ipilimumab
radiation therapy
stereotactic body radiotherapy (SBRT)
image-guided brachytherapy
intensity-modulated radiation therapy (IMRT)
external beam radiotherapy
high-dose-rate brachytherapy

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