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A 25-year-old man presents for evaluation of diarrhea. He is generally healthy and reports he finished a 4-day hike about 2 weeks ago. He does mention that he ran out of water on day 3 and did not have a filter with him. Today he feels "ok" but has had 24 hours of abdominal bloating, increased flatulence, and loose stools. He denies melena or hematochezia. His physical examination is unremarkable but stool ova and parasite examination reveal ova and trophozoites. Based on the most likely diagnosis, which of the following is the most appropriate first-line therapy for this patient?
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