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42.2 A 55-year-old female presents to the hospital with shortness of breath, fever, and malaise. She has a history of breast cancer, which was diagnosed 3 months ago, and has been treated with chemotherapy. Her chest x-ray shows possible pneumonia, and respiratory cultures are positive for Aspergillus fumigatus. Which of the following is the MOST appropriate choice for treatment?A. Voriconazole.B. Fluconazole.C. Flucytosine.D. Ketoconazole.
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- C. 46,XY,-21,rob(14;21)(q10;q10)All of the listed karyotypes are possible when this woman mates with a karyotypically normal male. However, 46, XY,-21, rob(14;21)(q10;q10) is trisomy 14, which is not viable and therefore would not be seen in the liveborn offspring of this couple. Of viable offspring in such a mating, 50% have a balanced translocation [ 45, XY,-14,- 21, rob(14;21)(q10;q10) or 45,XX,-14,-21,rob(14;21)(q10;q10)], 40% are karyotypically normal [46, XX] , and 10% have an unbalanced translocation and Down syndrome [46, XY,- 14, rob(14;21)(q10;q10)].