Pathology Questions
Explore questions in the Pathology category that you can ask Spark.E!
p53 is a protein with a ___________ half life present, in the normal situation, in very _________ concentrations in cells.
grading of cancer - degree of _______________
____________ corrects mismatched bases
__________ are central to adhesion, establish cell ______ and cell-cell ______________
staging of cancer - invasion and metastasis - guides ____________
p53 is a protector against ___________ oncogenes
MMR corrects ___________/___________ loops that most commonly occur where short sequences are repeated
what type of mutations occur in Lynch syndrome or Hereditary Non-Polyposis Colorectal Cancer (HNPCC)
squamous cell carcinomas the gene for the EGF-R can be amplified to many 100's of copies the cell is much more sensitive to ____________
in _________ of mismatch repair, mutation rate increases 100-1000x
TSGs are said to be "____________" in mechanism to wild type
in carcinomas cadherins, b catenin, APC are ________ or ___________
DNA strand break repair - what genes are involved in d/s break repair?
aneuploidy often involves ____________________ (deletion)
as angiogenesis of the tumour increases, what happens to it's size?
chromosomal rearrangements in solid tumours, particularly carcinomas, are extensive, but __________ characteristic of a specific cancer type
Transition from a growth regulated cell to a malignant cancer cell requires
When DNA is damaged, p53 is stabilised and its concentration _____
what controls the G1/S checkpoint?
Final cancer diagnosis almost always involves tissue diagnosis by