Pathology Questions
Explore questions in the Pathology category that you can ask Spark.E!
In genetics clinic, you are counseling five pregnant women who inquire about their risk for having a Down syndrome fetus. What are their risks and why?a. a 23-year-old mother of a previous trisomy 21 child b. a 41-year-old mother of a previous trisomy 21 child c. a 27-year-old woman whose niece has Downsyndromed. d. a carrier of a 14;21 Robertsonian translocatione. e. a woman whose husband is a carrier of a 14;21Robertsonian translocation
A young girl with Down syndrome is karyotyped and found to carry a 21q21q translocation. With use of standard cytogenetic nomenclature, what is her karyotype?
A baby girl with ambiguous genitalia is found to have 21-hydroxylase deficiency of the salt-wasting type. What karyotype would you expect to find? What is the disorder? What genetic counseling would you offer to the parents?
The cells of a multicellular organism become specialized for particular tasks and communicate with one another to maintain homeostasis
Polyploidy is common in nature and provides a major mechanism for adaptation and speciation.Approximately 50-70% of angiosperms, which include many crop plants, have undergone polyploidy during their evolutionary process.
majority of skin is made up of what layer?
both melanocytes and langerhans cells are _______________ cells
stratified squamous epithelium present in what layer?
Mutating p53 makes the cell genetically ______________
when ____ is bound to Rb,E 2F is _________________ from activating transcriptional
The development of __________ dimers in DNA is characteristic of UVR induced damage
if the process of melanocyte migration into skin from neural crest is disturbed, what can it cause?
Changes in adhesion are essential for _____
Tumour DNA/RNA may be extracted for __________ tests
Deregulation of both ___________ allows telomerase to overcome replicative senescence
if mutations occur in coding regions, what are they termed?
p53 is a protein with a ___________ half life present, in the normal situation, in very _________ concentrations in cells.
tumour suppressor genes - BOTH alleles must be _________ or __________ or _______________
granular layer - cells are _________ differentiated
oncogene activated can be detected by __________ which can induce the _______ pathway