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Directional selection is best described asall polymorphic alleles preserved in a populationT-cell receptor interaction with peptide:MHC complexes directed to a planar interfacea mechanism in T cells that is analogous to affinity maturation of immunoglobulinsselected alleles increase in frequency in a populationselection of most appropriate transplant donor directed at the identification of identical or similar combinations of HLA alleles compared with the transplant recipient.

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