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Where do the reactions of the citric acid cycle occur in eukaryotic cells?Across the inner membrane of the mitochondrionThe matrix of the mitochondrionThe cytosolThe cristae of the mitochondrionThe intermembrane space of the mitochondrion
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- defect in pyruvate oxidationdefect in the mitochondrial electron transport chainDefect in pyruvate oxidation will result in accumulation of pyruvate, which will then be converted to lactic acid via the lactic acid fermentation pathway. A defect in the ETC will prevent regeneration of NAD+ from NADH; high NADH and low NAD+ then cause pyruvate to be fermented to lactic acid.