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Why do patients suffering from Addison's disease display a phenotype associated with hypersecretion of melanin by melanocytes without increased plasma levels of \alphaαalpha-MSH, the primary melanocyte stimulating hormone in humans?Choice A, IAddison's disease is caused by a genetic mutation that renders melanocytes constitutively active.(Choice B, The similarity in the amino acid sequence of ACTH and \alphaαalpha-MSH allows ACTH to bind \alphaαalpha-MSH receptors under certain conditions.(Choice C,Addison's disease is associated with increased levels of glucocorticoids, which can be interconverted to \alphaαalpha-MSH by prohormoneconvertases secreted by melanocytes.(Choice D, Addison's disease is associated with decreased levels of glucocorticoids, which stimulate the production of ACTH via a positive feedback loop.
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