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Variolation- 既知の病原体や免疫系の知識よりも少なくとも400年前に行われていました!- 健康な人に天然痘(variola)に苦しんでいる人から少量の材料を与える- 中国の方法: - 天然痘のかさぶたを粉砕し、患者の鼻に吹き込む- インドや中東の方法: - ちょうど接種された人の膿疱を集める - それを1年間保存する - 患者の腕の皮膚を刺し、接種する- どちらの方法も、ほとんどの場合、軽い症状とその後の免疫をもたらしました。 - 典型的には、子供の1〜2%が死亡しました。 - 自然に感染した人の25〜30%に比べて、ということです。
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