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Sur la coupe histologique, on recherche : dans le chorion un infiltrat inflammatoire lymphocytaire qui, au début, entoure sélectivement l’extrémité des crêtes épithéliales, puis prend une disposition en bande à limite inférieure nette, « collée » à la face profonde de l’épithélium. Cet infiltrat est constitué essentiellement de lymphocytes T, mêlés à quelques macrophages et à quelques plasmocytes.Photo histologique : points noirs = lymphocytes T : on en voit partout sous l’épithélium. En réaction, l’épithélium produit beaucoup de kératine.Cela ne ressemble pas à la kératose réactionnelle car cette dernière a un chorion SAIN. Ici, on a un infiltrat inflammatoire et une modification des crêtes épithéliales et kératine en excès.La « lésion lichénoïde » de la zone de jonction chorion-épithélium est l’expression histologique essentielle du lichen plan.
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