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Spontaneous mutational "hotspots" occur at CG sequences in mammals where the C is methylated. The best explanation for the high number of mutations occurring at these sites is thatthe methylated cytosine deaminates to thymine.these CG sequences are prone to undergo unequal crossing over.deletions occur at a high frequency at these sites.the methylated cytosine mispairs with thymine often.None of the above explanations is correct.
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