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Phase with volunteers who have the disease or condition. The primary focus is a broad scale study of the drug's efficacy, and monitoring side effects.
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- Name: Thioamides: methimazole (Tapazole) tap shoes and Propulthiouracil/PTU (Propacil) (the hat is her PROP) MOA: prevents thyroid hormone synthesis by inhibiting thyroid peroxidase catalyzed rxns and blocking iodine organification. PTU also blocks T4 to T3 conversionIndications: MMI: hyperthyroidism (butterfly necklace). PTU: hyperthyroidism in pregnancy and breastfeeding, thyroid storm (rabbit coming out of the hat is pregnant) Adverse Effects: Rash, edema, agranulocytosis, hepatitis, cholestatic jaundice Contraindications: methimazole: pregnancy and breast feeding Interactions:Notes:
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