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NAME: SGLT-2 inhibitors: canagliflozin (Invokana), dapagliflozin (Farxiga), empagliflozin (Jardiance), and ertugliflozin (Steglatro)MOA: Inhibit the sodium glucose transporter-2 in the PCT of the kidney, preventing reabsorption of glucose and sodiumClinical: Clinically indicated for the treatment of hyperglycemia in T2DM, particularly in patients with heart failure and renal failure, also causes weight lossADME: Oral drugsAE: Yeast infections in women (~10%) and men (3-5%)UTIPolyuria (remember how glucose can be an osmotic diuretic?)NauseaHypotensionDyslipidemiaContraindications: Renal dialysis, hypersensitivityInteractions: May cause hypoglycemia when combined with insulin or insulin secretogoguesNotes: Monitor renal function and blood pressure in patients taking SGLT-2 inhibitors
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