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Melanie (pronouns: she/her/hers) has been taking sertraline for six months for depression. She noticed that her symptoms were not getting better, so she added St. John's wort as a supplement. St. John's wort can be used for depression, so she thought it would help. She developed an irregular heartbeat, confusion, and tremors and was then diagnosed with serotonin syndrome. What caused this reaction?
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