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•IP3 is the water soluble part (hydrophilic) of PIP2 and travels through the cytosol to stimulate Calcium release from ER. It interacts with its receptor (ITPR) in the membrane of the ER which allows the release of Ca2+ into the cytosol It also promotes Ca2+ influx from extracellular fluid by a mechanism that is less clear Increase in intracellular Ca2+ promoted cellular responses by it binding to calmodulin
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