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-Déregulation du cycle cell : la division cell n'est plus régulée => les cellules se divisent de manière anarchique sans recevoir d'ordre de division-Perte apoptose : (système de sauvegarde qd cell devient dangereuse) en cas de dysfcnmt du cycle cell, la cell ne peut plus etre supprimée -Perte sénescence : (limite le nb de divisions cell par un racourcissement des télomères jusqu'à une taille limite qui provoque l'arret définitif des division) la cell cancereuse produit la télomérase qui allonge les télomères après chaque réplication => ne rentrera pas en sénescence => cellules immortelles en division permanente
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