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Au niveau du foie : - Cytolyse - Hépatite aigüe - CirrhoseAu niveau des os/muscles : - Douleurs osseuses - MyalgiesAu niveau du SNC : - Hypertension intracrânienne (cf. IAM avec les tétracyclines) - Dépression - Céphalées (tentatives de suicide chez les patients déprimés)Au niveau de l’œil : - Opacités cornéennesAu niveau thyroïdien : - Hypothyroïdie => Rétinoïdes = agonistes du RXR => inhibition expression TSH => Surveiller la TSH et substituer si besoin en T4.
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