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A 47-year-old gentleman presents to the general practice for a hypertension review. Two months ago he was diagnosed with hypertension. He was initially started on ramipril. Four weeks ago it was found that this was not controlling his blood pressure, so amlodipine was added to his regime. On presentation today the gentleman's blood pressure is 161/91mmHg. You decide to try adding indapamide to his regime. Indapamide is a thiazide diuretic. Where in the nephron do thiazides primarily act?
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