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天然痘に関するいくつかの重要な事実が述べられています。- 天然痘の突然変異率は遅いです。- 天然痘は人間だけに感染します。- 症状が現れる前の感染力は最小限です。さらに、天然痘が他の病原体からいつ生じたかを特定するのは一般的な病原体よりも難しいと述べられています。これは、最近の気付きに基づいています。西アフリカと南アメリカのバージョンがお互いに最も類似していることが明らかになったためです。これらのバージョンがおそらく大西洋奴隷貿易の初期にお互いから分岐したと考えられています。このことから、天然痘がらくだ痘またはタテラポックスから生じたとされるのは約3000〜4000年前であることがわかります。
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