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1. Adsorption 2. Entrée du virus par fusion des membranes, la capside s'ouvre et ARN viral se trouve dans le cytoplasme3. Transcriptase inverse 4. Intégration : ADN importé dans le noyau, grâce à l'enzyme intégrase du virus il peut être intégrer dans l'ADN5. Transcription, traduction, former des protéines viral6. Assemblage : ARN et protéine se trouve au niveau de la membrane. Assemblage du génome et du capside (grâce à la séquence psi)7. Bourgeonnement : former de nouvelles particules viral, petit bourgeon de virus qui se forme et récupère les lipides d'enveloppe de la cellule hôte8. Relargage et maturation
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