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Les gènes qui codent les immunoglobulinesa.incluent des centaines de milliers de segments variables en situation germinaleb.ne deviennent fonctionnels qu'à l'issue de réarrangements somatiquesc.expriment les chaînes légères et lourdes d'une même immunoglobuline grâce à un épissage alternatif d'un seul ARNmd.incluent tous les isotypes des chaînes lourdes dans le même locus IGHe.ne sont exprimés que dans la lignée cellulaire B
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